Yes this is significant swelling. Treat it with Benadryl cream or hydrocortisone cream. You should also take a Benadryl pill . If the swelling doesn’t go down by Monday I’d let your doctor know and I’d definitely mention it the next time you get shots either way.
Maybe talk to them about a Benadryl flush or taking an antihistamine before shots? Idk what procedure you are following but this should definitely be mentioned.